Program: KPI-190

KPI-190 is a part of the ShK family and is being developed as an eye drop for use in several eye diseases including uveitis and Dry Eye Syndrome (DES).

Pathogenic T cells have been shown to play a role in autoimmune eye disease as T cell infiltration and cytokine and chemokine production lead to tissue damage in the eye. Kv1.3-HIGH autoreactive TEM cells have been identified in uveitis and DES making these conditions a good option for development of KPI-190.

  • KPI-190 is an eye drop being developed for several eye diseases
  • KPI-190 is a Kv1.3 inhibitor and is part of the ShK family
  • The ShK target has been found to be involved in diseases such as uveitis and dry eye syndrome

Therapeutic Need - Uveitis

Uveitis is one of the leading causes of blindness in the US and remains a significant unmet need. There are over 680,000 uveitis patients in the US with very few treatment options. Dry eye syndrome affects over 13 million people a year in the US alone and current treatments are either ineffective at treating the underlying disease or are toxic if used over long periods of time.

  • Uveitis is a leading cause of blindness
  • Over 680,000 people suffer from uveitis in the US
  • There are over 13 million DES patients in the US in need of new therapies

Development Status

KPI-190 has demonstrated proof of concept efficacy in models of anterior uveitis, and topically administered it has good penetration into the anterior chamber.

  • Proof-of-concept efficacy has been shown in uveitis models
  • The drop has good penetration into the eye

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